The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.
Johanna M MelinMaria ForslundSimon AlesiAnnemieke HoekDaniela RomualdiPoli Mara SpritzerChau Thien TayAlexia PenaSelma Feldman WitchelAya MousaHelena J TeedePublished in: European journal of endocrinology (2023)
Metformin should be considered as an efficacious adjunct to lifestyle interventions in adults with PCOS, especially for those with a higher BMI, to improve weight loss, insulin resistance and lipids.
Keyphrases
- polycystic ovary syndrome
- weight loss
- insulin resistance
- metabolic syndrome
- bariatric surgery
- physical activity
- roux en y gastric bypass
- gastric bypass
- weight gain
- adipose tissue
- high fat diet
- skeletal muscle
- body mass index
- cardiovascular disease
- glycemic control
- type diabetes
- high fat diet induced
- fatty acid
- clinical trial
- double blind
- phase iii
- study protocol