Gastric Cancer: Molecular Mechanisms, Novel Targets, and Immunotherapies: From Bench to Clinical Therapeutics.
Thais Baccili Cury MegidAbdul Rehman FarooqXin WangElena ElimovaPublished in: Cancers (2023)
Gastric cancer is a global health concern, ranking fifth in cancer diagnoses and fourth in cancer-related deaths worldwide. Despite recent advancements in diagnosis, most cases are detected at advanced stages, resulting in poor outcomes. However, recent breakthroughs in genome analysis have identified biomarkers that hold positive clinical significance for GC treatment. These biomarkers and classifications offer the potential for more precise diagnostic and therapeutic approaches for GC patients. In this review, we explore the classification and molecular pathways in this disease, highlighting potential biomarkers that have emerged in recent studies including targeted therapies and immunotherapies. These advancements provide a promising direction for improving the management of GC.
Keyphrases
- global health
- end stage renal disease
- ejection fraction
- newly diagnosed
- gas chromatography
- public health
- machine learning
- papillary thyroid
- prognostic factors
- peritoneal dialysis
- type diabetes
- mass spectrometry
- squamous cell
- genome wide
- metabolic syndrome
- gene expression
- skeletal muscle
- risk assessment
- climate change
- weight loss
- lymph node metastasis