Driving Role of Interleukin-2-Related Regulatory CD4+ T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of Systemic Sclerosis.

Camelia FrantzAnne CauvetAurélie DurandVirginie GonzalezRémi PierreMarcio Do CruzeiroKarine BaillyMuriel AndrieuCindy OrvainJérôme AvouacMina OttavianiRaphaël ThuilletLy TuChristophe GuignabertBruno LucasCédric AuffrayYannick Allanore

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Immunotherapies for restoring Treg cell homeostasis could be relevant in SSc. An intervention based on low-dose IL-2 injections, as is already proposed in other autoimmune diseases, could be the most suitable treatment modality for restoring Treg cell homeostasis for future research.

Keyphrases

systemic sclerosis
low dose
mouse model

single cell
cell therapy
randomized controlled trial

stem cells
combination therapy

replacement therapy
liver fibrosis