Stabilization of bicelles using metal-binding peptide for extended blood circulation.
Yuichiro TakagiNoriyuki UchidaYasutaka AnrakuTakahiro MuraokaPublished in: Chemical communications (Cambridge, England) (2022)
A metal-binding peptide appending cholic acid, Chol-MBP, formed bicelles by mixing with 1,2-dipalmitoyl- sn-glycero -3-phosphorylcholine (DPPC). Coordination of Chol-MBP with Cu 2+ stabilized DPPC bicelles against dilution and contamination of serum proteins, enabling extended blood circulation. This study demonstrates an effective supramolecular design of phospholipid bicelles with enhanced stability useful for membrane-based biomaterials.