Remote ischemic postconditioning protects against crush-induced acute kidney injury via down-regulation of apoptosis and senescence.

Heng JinXiaoxi LinZiquan LiuJinqiang WangJinxiang WangYan ZhangChao CaoYanfen ChaiSongtao Shou

Published in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2022)

Performing 5 cycles of 1-min IPC would be a convenient, time-saving, and effective method to prevent crush-induced AKI by attenuating the release of nephrotoxic substances after decompression and downregulation of the expression of apoptosis and cellular senescence biomarkers.

Keyphrases

acute kidney injury
high glucose
oxidative stress
diabetic rats
endothelial cells
endoplasmic reticulum stress
dna damage
cell cycle arrest
cell death
ischemia reperfusion injury
cardiac surgery
poor prognosis
drug induced
stress induced
signaling pathway
binding protein
cerebral ischemia
pi k akt