Is radiotherapy required in first-line treatment of stage I diffuse anaplastic Wilms tumor? A report of SIOP-RTSG, AIEOP, JWiTS, and UKCCSG.
Raquel Davila FajardoMarry M van den Heuvel-EibrinkHarm van TinterenFilippo SpreaficoThomas AchaChristophe BergeronBeatriz de CamargoFoppe OldenburgerChristian RübeTakaharu OueChristian VokuhlRonald R de KrijgerGordan M VujanicNeil SebireAurore Coulomb-L'HerminePaola ColliniLorenza GandolaKathy Pritchard-JonesNorbert GrafGeert O JanssensMartine van GrotelPublished in: Pediatric blood & cancer (2019)
Despite 13% locoregional relapse rate, an excellent rescue rate was achieved after salvage treatment, in patients with stage I DAWT whose first-line treatment comprised three-drug chemotherapy (including doxorubicin), without flank irradiation. Therefore, we continue not to advocate the use of radiotherapy in first-line treatment after preoperative chemotherapy in stage I DAWT in the next SIOP protocol.