Intrahepatic interleukin 10 expression modulates fibrinogenesis during chronic HCV infection.
Ednelza da Silva Graça AmorasSamara Tatielle Monteiro GomesMaria Alice Freitas QueirozMauro Sergio Moura de AraújoMarialva Tereza Ferreira de AraújoSimone Regina Souza da Silva CondeRicardo IshakAntonio Carlos Rosário VallinotoPublished in: PloS one (2020)
Intrahepatic IL10 mRNA expression decreases with persistent fibrosis, probably due to the production of TGF-β1, a potent antimitotic and fibrogenic cytokine. IL10 restricts and decreases the immune response and limits the fibrogenic response; however, a decrease in IL10 favors persistent inflammatory infiltrate, resulting in severe fibrosis.