Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis.
Yara-Natalie AboNigel CurtisJoshua OsowickiGabrielle HaeuslerRachael PurcellSeilesh KadambariMatthias De WachterKoen Vanden DriesscheSven DekeyzerLee ColemanNigel CrawfordSteve GrahamBen MaraisAmanda GweePublished in: Journal of the Pediatric Infectious Diseases Society (2021)
Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.
Keyphrases
- mycobacterium tuberculosis
- hiv infected
- ulcerative colitis
- hiv aids
- antiretroviral therapy
- blood brain barrier
- pulmonary tuberculosis
- cerebrospinal fluid
- hiv positive
- randomized controlled trial
- human immunodeficiency virus
- young adults
- hepatitis c virus
- systematic review
- hiv testing
- emergency department
- early onset
- men who have sex with men
- drug induced
- electronic health record