[Covalently conjugated DNA aptamer with doxorubicin as in vitro model for effective targeted drug delivery to human glioblastoma tumor cells].

Ya A Sliman N S Samoylenkova O A Antipova Vladimir A BrylevD A VeryutinKsenia A Sapozhnikova A I Alekseeva I N Pronin Alexey M Kopylov Galina Valerievna Pavlova

Published in: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko (2024)

We established obvious antiproliferative effect of covalent conjugate DOX-GR20 on continuous human glioblastoma cell culture Sus/fP2 without toxic effect on the reference culture (dermal fibroblasts DF1).

Keyphrases

drug delivery
cancer therapy
endothelial cells
induced pluripotent stem cells
pluripotent stem cells
photodynamic therapy
circulating tumor
extracellular matrix
magnetic nanoparticles