A transcriptomic model for homologous recombination deficiency in prostate cancer.
Adam B WeinerYang LiuMatthew McFarlanePushpinder Singh BawaEric V LiXin ZhaoZiwen LiTanya HammoudMunna HazimeR Jeffrey KarnesElai DavicioniZachery R ReichertArul M ChinnaiyanTamara L LotanDaniel E SprattEdward M SchaefferPublished in: Prostate cancer and prostatic diseases (2021)
These results suggest transcriptomics can identify more patients that harbor phenotypic HRD than single HR-gene mutations and support further exploration of transcriptionally defined HRD tumors perhaps in conjunction with genomic markers for therapeutic application.