Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials.
Amy E SmithArjun MuralidharanMaree T SmithPublished in: Discover. Oncology (2022)
There is a knowledge gap for clinical trials of chemotherapy, small molecule inhibitors and/or immunotherapy in patients with PCIBP where pain response is the primary endpoint. Also, there are no novel analgesic agents on the horizon for the relief of PCIBP and this is an area of large unmet medical need that warrants concerted research attention.
Keyphrases
- clinical trial
- chronic pain
- neuropathic pain
- prostate cancer
- small molecule
- pain management
- healthcare
- spinal cord
- randomized controlled trial
- radical prostatectomy
- working memory
- oxidative stress
- bone mineral density
- high glucose
- postoperative pain
- soft tissue
- diabetic rats
- radiation therapy
- study protocol
- body composition
- stress induced