Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors.
Luana Guimaraes de SousaDaniel J McGrailFelippe Lazar NetoKaiyi LiMario L Marques-PiubelliSammy Ferri-BorgognoHui DaiYoshitsugu MitaniNicole Spardy BurrZachary A CooperKrista KinneerMaria Angelica CortezShiaw-Yih LinDiana BellAdel K El-NaggarJared K BurksRenata FerrarottoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Spatial analysis revealed that ACC subtypes have distinct TMEs, with enrichment of ACC-I immune cells that are restricted to the stroma. B7-H4 is highly expressed in poor-prognosis ACC-I subtype and is a potential therapeutic target.