Dietary canolol protects the heart against the deleterious effects induced by the association of rapeseed oil, vitamin E and coenzyme Q10 in the context of a high-fat diet.
Thibault LegerIsabelle Hininger-FavierFrédéric CapelAlain GeloenJean-Paul RigaudièreChrystèle JouveElodie PitoisGaelle PineauCarole VaysseJean-Michel ChardignyMarie-Caroline MichalskiCorinne Malpuech-BrugèreLuc DemaisonPublished in: Nutrition & metabolism (2018)
Canolol was found to counteract the fibrotic effects of vitamin E + CoQ10 on cardiac fibrosis in the context of a high-fat diet enriched with RSO. This effect occurred through a restoration of cardiac Ag2R-1b mRNA expression and decreased ischemia.