CSF1-associated decrease in endometrial macrophages may contribute to Asherman's syndrome.

Dan LiuJiali WangGuangfeng ZhaoPeipei JiangMinmin SongHailin DingZhiyin WangHaining LvYa L Hu

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)

Macrophages are critical cells involved in the process of endometrial repair and fibrosis. The decreased amount of endometrial macrophages may be attributed to the reduced expression level of CSF1. Manipulation of macrophage activation/function may provide a novel therapeutic target for AS.

Keyphrases

endometrial cancer
induced apoptosis
poor prognosis
cell cycle arrest
adipose tissue
binding protein
cerebrospinal fluid
oxidative stress
signaling pathway
long non coding rna
cell death
pi k akt
liver fibrosis