Mucoadhesive Microspheres of Maraviroc and Tenofovir Designed for Pre-Exposure Prophylaxis of HIV-1: An in vitro Assessment of the Effect on Vaginal Lactic Acid Bacteria Microflora.
Sabdat O EkamaMargaret Okonawan IlomuanyaChukwuemeka P AzubuikeTajudeen A BamideleMuinah Adenike FoworaOluwagbemiga O AinaOliver Chukwujekwu EzechiCecilia I IgwiloPublished in: HIV/AIDS (Auckland, N.Z.) (2021)
The antiretroviral drugs loaded in the microspheres, had good mucoadhesion which is a potential for prolonged residence time in the vagina. The antiretroviral drugs were adequately released from the microspheres and showed efficacy against the HIV-1 BaL virus strain. There was no significant disruption in the growth of the lactic acid bacteria which constitute valuable bacteria microflora of the vagina.