A modified Delphi approach to develop a trial protocol for antibiotic de-escalation in patients with suspected sepsis.
Michael E YarringtonRebekah W MoehringMichael Z DavidKeith W HamiltonMichael KlompasChanu RheeKevin HsuehElizabeth Dodds AshleyRonda L Sinkowitz-CochranMatthew RyanDeverick J Andersonnull nullPublished in: Antimicrobial stewardship & healthcare epidemiology : ASHE (2021)
The modified Delphi approach is a useful method to achieve expert-level consensus in the absence of evidence suifficient to provide validated guidance. The Delphi approach allowed for flexibility in development of an opt-out trial protocol for sepsis antibiotic de-escalation. The utility of this protocol should be evaluated in a randomized controlled trial.