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A modified Delphi approach to develop a trial protocol for antibiotic de-escalation in patients with suspected sepsis.

Michael E YarringtonRebekah W MoehringMichael Z DavidKeith W HamiltonMichael KlompasChanu RheeKevin HsuehElizabeth Dodds AshleyRonda L Sinkowitz-CochranMatthew RyanDeverick J Andersonnull null
Published in: Antimicrobial stewardship & healthcare epidemiology : ASHE (2021)
The modified Delphi approach is a useful method to achieve expert-level consensus in the absence of evidence suifficient to provide validated guidance. The Delphi approach allowed for flexibility in development of an opt-out trial protocol for sepsis antibiotic de-escalation. The utility of this protocol should be evaluated in a randomized controlled trial.
Keyphrases
  • randomized controlled trial
  • study protocol
  • phase iii
  • open label
  • acute kidney injury
  • intensive care unit
  • clinical trial
  • phase ii
  • septic shock
  • clinical practice