Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials.
Gareth Zigui LimJonathan Yexian LaiChristopher Ying Hao SeetCarol Huilian ThamNarayanaswamy VenketasubramanianBenjamin Yong Qiang TanMingxue JingJoshua Yee Peng YeoMay Zin MyintChing-Hui SiaHock Luen TeohVijay Kumar SharmaBernard Poon Lap ChanCunli YangAndrew MakmurShao Jin OngLeonard Leong-Litt YeoPublished in: Journal of cardiovascular development and disease (2023)
Endovascular therapy (EVT) has revolutionized the management of acute ischaemic strokes with large vessel occlusion, with emerging evidence suggesting its benefit also in large infarct core volume strokes. In the last two years, four randomised controlled trials have been published on this topic-RESCUE-Japan LIMIT, ANGEL-ASPECT, SELECT2 and TENSION, with overall results showing that EVT improves functional and neurological outcomes compared to medical management alone. This review aims to summarise the recent evidence presented by these four trials and highlight some of the limitations in our current understanding of this topic.