Characterization of EpCAM in thyroid cancer biology by three-dimensional spheroids in vitro model.
Viola GhiandaiElisa Stellaria GrassiGiacomo GazzanoLaura FugazzolaLuca PersaniPublished in: Cancer cell international (2024)
Our data provide novel information on the role of EpCAM expression and cleavage in the biology of thyroid TICs, and our 3D model reflects the variability of EpCAM cleavage observed in tissue samples. EpCAM evaluation could play a role in clinical decisions regarding patient therapy since its expression and cleavage may have a fundamental role in the switch to a drug-resistant phenotype of UTC cells.
Keyphrases
- drug resistant
- cell adhesion
- circulating tumor cells
- poor prognosis
- multidrug resistant
- dna binding
- acinetobacter baumannii
- induced apoptosis
- binding protein
- healthcare
- case report
- electronic health record
- big data
- signaling pathway
- machine learning
- stem cells
- data analysis
- bone marrow
- cystic fibrosis
- artificial intelligence
- mesenchymal stem cells