Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes.
Yuhan QiuAndrew ChenRebecca YuPablo LlevenesMichael SeenNaomi Y KoStephano MontiGerald V DenisPublished in: bioRxiv : the preprint server for biology (2024)
IR adipocyte exosomes modify TME, increase EMT and promote metastasis to distant organs, likely through miRNA pathways. We suggest metabolic diseases such as T2D reshape the TME, promoting metastasis and decreasing survival. Therefore, TNBC patients with T2D should be closely monitored for metastasis, with metabolic medications considered.
Keyphrases
- insulin resistance
- adipose tissue
- mesenchymal stem cells
- stem cells
- metabolic syndrome
- high fat diet
- type diabetes
- fatty acid
- epithelial mesenchymal transition
- skeletal muscle
- white matter
- multiple sclerosis
- signaling pathway
- bone marrow
- high fat diet induced
- resting state
- weight loss
- free survival
- cerebral ischemia
- subarachnoid hemorrhage