Effects of conditioned media derived from human Wharton's jelly mesenchymal stem cells on diabetic nephropathy and hepatopathy via modulating TGF-β and apelin signaling pathways in male rats.

Zeinab KarimiGholamreza DaryaborFatemeh Masjedi

Published in: BMC endocrine disorders (2024)

Human WJ-MSCs-CM may have protective effects on diabetic renal and hepatic complications. These effects may happen through the regulation of TGF-β and apelin signaling pathways.

Keyphrases

mesenchymal stem cells
signaling pathway
diabetic nephropathy
endothelial cells
umbilical cord
transforming growth factor
induced pluripotent stem cells
type diabetes
pluripotent stem cells
epithelial mesenchymal transition
risk factors
bone marrow
wound healing
induced apoptosis