Casticin promotes osteogenic differentiation of bone marrow stromal cells and improves osteoporosis in rats by regulating nuclear factor-κB/mitogen-activated protein kinase.

Dong ZhangXuejia LiJianmin LiWanxin LiuYing YuShuqiang WangXiaojian Ye

Published in: International journal of rheumatic diseases (2022)

CAS promoted osteogenic differentiation of BMSCs and improved osteoporosis in rats by regulating the NF-κB/MAPK pathway. This might shed a light into using CAS as a drug treating osteoporosis in the future.

Keyphrases

nuclear factor
postmenopausal women
bone mineral density
bone marrow
toll like receptor
crispr cas
genome editing
signaling pathway
oxidative stress
pi k akt
mesenchymal stem cells
body composition
current status
emergency department
protein kinase
cell proliferation