Alterations of Nedd4-2-binding capacity in PY-motif of NaV 1.5 channel underlie long QT syndrome and Brugada syndrome.

Ya WangYuan DuLing LuoPeijing HuGuodong YangTao LiXiu HanAiqun MaTingzhong Wang

Published in: Acta physiologica (Oxford, England) (2020)

Our data suggest that the PY-motif plays an essential role in modifying the expression/function of NaV 1.5 channels through Nedd4-2-mediated ubiquitination. Alterations of NaV 1.5-Nedd4-2 interaction represent a novel pathological mechanism for NaV 1.5 channel diseases caused by SCN5A variants.

Keyphrases

poor prognosis
case report
binding protein
copy number
electronic health record
big data
gene expression
drug induced
dna methylation
long non coding rna
artificial intelligence
data analysis