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Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice.

Naoyuki KawaoMiku KawaguchiTakashi OhiraHiroki EharaYuya MizukamiYoshimasa TakafujiHiroshi Kaji
Published in: Journal of cachexia, sarcopenia and muscle (2022)
The present results demonstrated that renal failure decreases the expression of irisin in the gastrocnemius muscles of mice. Irisin may contribute to cortical bone loss induced by renal failure in mice as a myokine linking muscle to bone.
Keyphrases
  • bone loss
  • high fat diet induced
  • poor prognosis
  • skeletal muscle
  • binding protein
  • signaling pathway
  • type diabetes
  • insulin resistance
  • metabolic syndrome
  • long non coding rna
  • bone mineral density