Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism.
Christopher R M AsquithLidia S KonstantinovaTuomo LaitinenMarina Luisa MeliAntti PosoOleg A RakitinRegina Hofmann-LehmannStephen T HiltonPublished in: ChemMedChem (2016)
A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- induced apoptosis
- men who have sex with men
- oxide nanoparticles
- cell cycle arrest
- south africa
- oxidative stress
- molecular docking
- cell death
- amino acid
- binding protein
- small molecule
- human health
- endoplasmic reticulum stress