Login / Signup

AURKB promotes bladder cancer progression by deregulating the p53 DNA damage response pathway via MAD2L2.

Linzhi LiPengcheng JiangWeimin HuFan ZouMing LiTing RaoYuan RuanWeimin YuJinzhuo NingFan Cheng
Published in: Journal of translational medicine (2024)
AURKB activates MAD2L2 expression to downregulate the p53 DDR pathway, thereby promoting BC progression. Thus, AURKB may serve as a potential molecular marker and a novel anticancer therapeutic target for BC.
Keyphrases
  • dna damage response
  • poor prognosis
  • dna repair
  • single molecule
  • climate change
  • muscle invasive bladder cancer