Concurrent therapy with immune checkpoint inhibitors and TNFα blockade in patients with gastrointestinal immune-related adverse events.

Yousef R BadranJustine V CohenPriscilla K BrastianosAparna R ParikhTheodore S HongMichael L Dougan

Published in: Journal for immunotherapy of cancer (2019)

Concurrent treatment with anti-TNFα and ICI appears to be safe, facilitates steroid tapering, and prevents irEC. Prospective clinical trials are needed to assess the outcomes of this treatment modality.

Keyphrases

clinical trial
rheumatoid arthritis
randomized controlled trial
metabolic syndrome
bone marrow
adipose tissue
replacement therapy
cell therapy
double blind