Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis.
Marzia RossatoAlsya J AffandiSoley ThordardottirCatharina G K WichersMarta CossuJasper C A BroenFrederique M MoretLara Bossini-CastilloEleni ChouriLenny van BonFemke WoltersWioleta MarutMaarten van der KroefSandra Silva-CardosoCornelis P J BekkerHarry DolstraJacob M van LaarJavier MartinJoel A G van RoonKris A ReedquistLorenzo BerettaTimothy R D J RadstakePublished in: Arthritis & rheumatology (Hoboken, N.J.) (2017)
Up-regulation of miR-618 suppresses the development of PDCs and increases their ability to secrete IFNα, potentially contributing to the type I IFN signature observed in SSc patients. Considering the importance of PDCs in the pathogenesis of SSc and other diseases characterized by a type I IFN signature, miR-618 potentially represents an important epigenetic target to regulate immune system homeostasis in these conditions.
Keyphrases
- dendritic cells
- systemic sclerosis
- immune response
- cell proliferation
- regulatory t cells
- long non coding rna
- interstitial lung disease
- end stage renal disease
- poor prognosis
- long noncoding rna
- newly diagnosed
- ejection fraction
- chronic kidney disease
- dna methylation
- gene expression
- signaling pathway
- rheumatoid arthritis