Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer.
Gene Chi Wai ManJianzhang WangYi SongJack Ho WongYu ZhaoTat San LauKam Tong LeungTak Hang ChanHuating WangJoseph KwongTzi Bun NgChi Chiu WangPublished in: BMC cancer (2020)
Taken together, ProEGCG at a low dose exhibited anticancer activity in EC cells through its anti-proliferative, pro-apoptotic and anti-tumor actions on endometrial cancer in vitro and in vivo. In contrast, a low dose of EGCG did not bring about similar effects. Importantly, our data demonstrated the efficacy and safety of ProEGCG which manifests the potential of a novel anticancer agent for the management of endometrial cancer.
Keyphrases
- endometrial cancer
- signaling pathway
- low dose
- induced apoptosis
- cell cycle arrest
- pi k akt
- cell death
- oxidative stress
- endoplasmic reticulum stress
- anti inflammatory
- high dose
- epithelial mesenchymal transition
- endothelial cells
- cell proliferation
- magnetic resonance
- electronic health record
- pluripotent stem cells
- cancer therapy
- induced pluripotent stem cells
- drug delivery
- risk assessment
- climate change
- data analysis
- artificial intelligence