Oleic acid-PPARγ-FABP4 loop fuels cholangiocarcinoma colonization in lymph node metastases microenvironment.
Honghua ZhangKe ZhuRui ZhangYabin GuoJin WangChaoqun LiuXinjun LuZiyu ZhouWenrui WuFapeng ZhangZhixiao SongShusheng LinCaini YangXiuxian LiYang LiuQibin TangXianhuan YuLei-Bo XuChao LiuPublished in: Hepatology (Baltimore, Md.) (2024)
Our results reveal the role of the oleic acid-PPARγ-fatty acid-binding protein 4 loop in fueling cholangiocarcinoma colonization in lymph nodes and demonstrate that PPARγ-regulated lipid metabolic reprogramming is a promising therapeutic target for relieving cholangiocarcinoma lymph node metastasis burden and reducing further progression.
Keyphrases
- lymph node
- fatty acid
- lymph node metastasis
- binding protein
- transcription factor
- insulin resistance
- sentinel lymph node
- neoadjuvant chemotherapy
- squamous cell carcinoma
- papillary thyroid
- stem cells
- genome wide
- risk factors
- single cell
- type diabetes
- skeletal muscle
- gene expression
- early stage
- dna methylation
- rectal cancer
- locally advanced