Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia: An Overview of Systematic Reviews.
Peijie HeJuan LiangWanjun ZhangShengyun LinHanting WuQiushuang LiXiujuan XuConghua JiPublished in: International journal of clinical practice (2022)
Current SRs show that allo-SCT in the treatment of AML might improve the OS, RFS, and DFS. Auto-SCT has significantly lower TRM but higher RR. Whether bone marrow transplantation is superior to nonmyeloablative chemotherapy remains to be evaluated. Meanwhile, the quality of methodology needs to be further improved. The intensity of evidence was uneven, and the high-quality evidence of outcomes was lacking. Considering the limitations of our overview, more rigorous and scientific studies are needed to fully explore the efficacy of different interventions of HSCT in AML, and clinicians should be more cautious in the treatment.
Keyphrases
- acute myeloid leukemia
- bone marrow
- allogeneic hematopoietic stem cell transplantation
- systematic review
- mesenchymal stem cells
- physical activity
- type diabetes
- palliative care
- randomized controlled trial
- locally advanced
- high intensity
- metabolic syndrome
- adipose tissue
- skeletal muscle
- replacement therapy
- cell therapy
- acute lymphoblastic leukemia