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Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model.

Kimberly Z HeadOluwanifemi E BolatimiTyler C GripshoverMin TanYan LiTimothy N AudamSteven P JonesCarolyn M KlingeMatthew C CaveBanrida Wahlang
Published in: Frontiers in gastroenterology (Lausanne, Switzerland) (2023)
Overall, the results demonstrated that longer-term PCB exposure worsened TAFLD outcomes independent of HFD feeding and suggests altered energy metabolism as a potential mechanism fueling PCB mediated toxicity without dietary insult. Additional research exploring mechanisms for these longer-term PCB mediated toxicity in TAFLD is warranted.
Keyphrases
  • mouse model
  • preterm infants
  • oxidative stress
  • metabolic syndrome
  • insulin resistance
  • type diabetes
  • gestational age
  • weight loss
  • high fat diet
  • fatty acid
  • oxide nanoparticles
  • glycemic control