Anti-apoptotic effects of adipose-derived adherent stromal cells in mesenchymal stem cells exposed to oxidative stress.
Sunhye ShinJung-Won ChoiSoyeon LimSeahyoung LeeEun-Young JunHyun-Min SunIl-Kwon KimHoon-Bum LeeSang-Woo KimKi-Chul HwangPublished in: Cell biochemistry and function (2018)
We investigated the expression levels of proteins associated with oxidation, inflammation, and apoptosis in MSCs co-cultured with isolated ADASs from 6 donors' SVFs under oxidative stress conditions. Our results imply that isolated ADASs from SVFs may inhibit oxidative stress-induced cell cycle arrest and/or apoptosis in MSCs via a p53-dependent pathway. Furthermore, we identified an anti-apoptotic mechanism involving oxidative stress-induced apoptosis by adipose-derived ADASs in MSCs for the first time. Our findings suggest that the positive effects of SVF implantation into damaged heart tissue may be attributed to the various actions of MSCs.
Keyphrases
- oxidative stress
- mesenchymal stem cells
- induced apoptosis
- cell cycle arrest
- cell death
- umbilical cord
- endoplasmic reticulum stress
- diabetic rats
- ischemia reperfusion injury
- dna damage
- pi k akt
- bone marrow
- cell therapy
- signaling pathway
- poor prognosis
- heart failure
- atrial fibrillation
- anti inflammatory
- endothelial cells
- hydrogen peroxide
- kidney transplantation
- heat shock
- nitric oxide
- long non coding rna
- heat shock protein
- single molecule