Chromosomal rearrangements and protein globularity changes in Mycobacterium tuberculosis isolates from cerebrospinal fluid.
Seow Hoon SawJoon Liang TanXin Yue ChanKok Gan ChanYun Fong NgeowPublished in: PeerJ (2016)
The occurrence of in silico genetic differences in CSF-derived but not respiratory Mtb suggests their possible involvement in the pathogenesis of TBM. However, overall findings in this comparative analysis support the postulation that TB meningeal infection is more likely to be related to the expression of multiple virulence factors on interaction with host defences than to CNS tropism associated with specific genetic traits.
Keyphrases
- mycobacterium tuberculosis
- cerebrospinal fluid
- genome wide
- copy number
- pulmonary tuberculosis
- poor prognosis
- escherichia coli
- pseudomonas aeruginosa
- risk assessment
- staphylococcus aureus
- binding protein
- dna methylation
- molecular docking
- antimicrobial resistance
- biofilm formation
- cystic fibrosis
- amino acid
- long non coding rna