High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.

Eugene C ChenPär MatssonMina AzimiXujia ZhouNiklas HandinSook Wah YeePer ArturssonKathleen M Giacomini

Published in: Pharmaceutical research (2022)

This study represents the largest screen to identify prescription drug inhibitors of OCT3. Several are sufficiently potent to inhibit the transporter at therapeutic unbound plasma levels, potentially leading to DDIs or off-target pharmacologic effects.

Keyphrases

optical coherence tomography
diabetic retinopathy
adverse drug
ionic liquid
emergency department
drug induced
optic nerve
anti inflammatory
electronic health record
water soluble