Kathleen M Giacomini (Kathleen Giacomini)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 54

Top Topics

Cerebral Ischemia

Pluripotent Stem Cells

Top Venues

Clinical pharmacology and therapeutics

Nature communications

Nature reviews. Drug discovery

This page only lists publications with an associated author ORCID identifier.

Publications

Rosemary J Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C Choy, Zhening Zhang, Aditya Katewa, Amara Larpthaveesarp, Eric J Huang, Scott W J Mooney, Oliver B Clarke, Sook Wah Yee, Kathleen M Giacomini, Anthony A Kossiakoff, Matthias Quick, Thomas D Arnold, Filippo Mancia
Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature 629 (8012) (2024)
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin M Brand, Finn D Wolfreys, Jia Yang, Jason E Gestwicki, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. Nature communications 15 (1) (2024)
Xujia Zhou, Mina Azimi, Niklas Handin, Andrew M Riselli, Bianca Vora, Eden Chun, Sook Wah Yee, Per Artursson, Kathleen M Giacomini
Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier. bioRxiv : the preprint server for biology (2024)
Rosemary J Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C Choy, Zhening Zhang, Aditya Katewa, Amara Larpthaveesarp, Eric J Huang, Scott W J Mooney, Oliver B Clarke, Sook Wah Yee, Kathleen M Giacomini, Anthony A Kossiakoff, Matthias Quick, Thomas D Arnold, Filippo Mancia
Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery 23 (4) (2024)
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin M Brand, Finn D Wolfreys, Jia Yang, Jason E Gestwicki, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. Nature communications 15 (1) (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery 23 (4) (2024)
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin M Brand, Finn D Wolfreys, Jia Yang, Jason E Gestwicki, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. Nature communications 15 (1) (2024)
Liang Zhao, Kathleen M Giacomini, Piet H van der Graaf
Progress in Clinical Pharmacology in China: A Randomized Controlled Study to Advance Genotype-Guided Precision Medicine. Clinical pharmacology and therapeutics 115 (2) (2024)
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin M Brand, Finn D Wolfreys, Jia Yang, Jason E Gestwicki, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. Nature communications 15 (1) (2024)
Liang Zhao, Kathleen M Giacomini, Piet H van der Graaf
Progress in Clinical Pharmacology in China: A Randomized Controlled Study to Advance Genotype-Guided Precision Medicine. Clinical pharmacology and therapeutics 115 (2) (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery (2024)
Liang Zhao, Kathleen M Giacomini, Piet H van der Graaf
Progress in Clinical Pharmacology in China: A Randomized Controlled Study to Advance Genotype-Guided Precision Medicine. Clinical pharmacology and therapeutics 115 (2) (2024)
Rosemary J Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C Choy, Zhening Zhang, Aditya Katewa, Amara Larpthaveesarp, Eric J Huang, Scott W J Mooney, Oliver B Clarke, Sook Wah Yee, Kathleen M Giacomini, Anthony A Kossiakoff, Matthias Quick, Thomas D Arnold, Filippo Mancia
Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature (2024)
Rosemary J Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C Choy, Zhening Zhang, Aditya Katewa, Amara Larpthaveesarp, Eric J Huang, Scott W J Mooney, Oliver B Clarke, Sook Wah Yee, Kathleen M Giacomini, Anthony A Kossiakoff, Matthias Quick, Thomas D Arnold, Filippo Mancia
Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature 629 (8012) (2024)
Rosemary J Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C Choy, Zhening Zhang, Aditya Katewa, Amara Larpthaveesarp, Eric J Huang, Scott W J Mooney, Oliver B Clarke, Sook Wah Yee, Kathleen M Giacomini, Anthony A Kossiakoff, Matthias Quick, Thomas D Arnold, Filippo Mancia
Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature 629 (8012) (2024)
Sook Wah Yee, Joanne Wang, Kathleen M Giacomini
Rare Diseases Linked to Mutations in Vitamin Transporters Expressed in the Human Blood-Brain Barrier. Clinical pharmacology and therapeutics (2024)
Rosemary J Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C Choy, Zhening Zhang, Aditya Katewa, Amara Larpthaveesarp, Eric J Huang, Scott W J Mooney, Oliver B Clarke, Sook Wah Yee, Kathleen M Giacomini, Anthony A Kossiakoff, Matthias Quick, Thomas D Arnold, Filippo Mancia
Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature 629 (8012) (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery 23 (4) (2024)
Rosemary J Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C Choy, Zhening Zhang, Aditya Katewa, Amara Larpthaveesarp, Eric J Huang, Scott W J Mooney, Oliver B Clarke, Sook Wah Yee, Kathleen M Giacomini, Anthony A Kossiakoff, Matthias Quick, Thomas D Arnold, Filippo Mancia
Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature (2024)
Xujia Zhou, Mina Azimi, Niklas Handin, Andrew M Riselli, Bianca Vora, Eden Chun, Sook Wah Yee, Per Artursson, Kathleen M Giacomini
Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier. bioRxiv : the preprint server for biology (2024)
Rosemary J Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C Choy, Zhening Zhang, Aditya Katewa, Amara Larpthaveesarp, Eric J Huang, Scott W J Mooney, Oliver B Clarke, Sook Wah Yee, Kathleen M Giacomini, Anthony A Kossiakoff, Matthias Quick, Thomas D Arnold, Filippo Mancia
Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature 629 (8012) (2024)
Rosemary J Cater, Dibyanti Mukherjee, Eva Gil Iturbe, Satchal K Erramilli, Ting Chen, Katie Koo, Nicolás Santander Grez, Andrew Reckers, Brian Kloss, Tomasz Gawda, Brendon C Choy, Zhening Zhang, Aditya Katewa, Amara Larpthaveesarp, Eric J Huang, Scott W J Mooney, Oliver B Clarke, Sook Wah Yee, Kathleen M Giacomini, Anthony A Kossiakoff, Matthias Quick, Thomas D Arnold, Filippo Mancia
Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature 629 (8012) (2024)
Bianca Vora, Anita Wen, Sook Wah Yee, Kim Trinh, Mina Azimi, Elizabeth A E Green, Marina Sirota, Andrew S Greenberg, John W Newman, Kathleen M Giacomini
The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clinical pharmacology and therapeutics (2023)
Karthik Venkatakrishnan, Karen E Brown, Kathleen M Giacomini, Piet H van der Graaf
Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All. Clinical pharmacology and therapeutics 113 (3) (2023)
Kathleen M Giacomini
Biomarkers Come of Age in Clinical Pharmacology. Clinical pharmacology and therapeutics 113 (5) (2023)
D Max Smith, Iris K Minichmayr, Joseph F Standing, Kathleen M Giacomini, Piet H van der Graaf, Richard Wilson Peck
Ensuring Transparency and Quality of Clinical Trial Reporting in Clinical Pharmacology & Therapeutics: Prospective Trial Registration and Compliance with Reporting Guidelines Are Required for all Clinical Trials. Clinical pharmacology and therapeutics 114 (6) (2023)
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin M Brand, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini
Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates. bioRxiv : the preprint server for biology (2023)
Matthew E Michel, Christopher C Wen, Sook Wah Yee, Kathleen M Giacomini, Amro Hamdoun, Sascha C T Nicklisch
TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters. Clinical pharmacology and therapeutics (2023)
Karthik Venkatakrishnan, Karen E Brown, Kathleen M Giacomini, Piet H van der Graaf
Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All. Clinical pharmacology and therapeutics 113 (3) (2023)
Kathleen M Giacomini, Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn, Claudia Fontsere, Merve Ceylan, Megan Koleske, Niklas Handin, Virginia Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin Brand, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet
Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates. Research square (2023)
Iris K Minichmayr, D Max Smith, Kathleen M Giacomini, Piet H van der Graaf
Trends in Clinical Pharmacology and Therapeutics. Clinical pharmacology and therapeutics 114 (1) (2023)
Karthik Venkatakrishnan, Karen E Brown, Kathleen M Giacomini, Piet H van der Graaf
Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All. Clinical pharmacology and therapeutics 113 (3) (2023)
Kathleen M Giacomini, Shiew Mei Huang
More Than Pharmacokinetics: Transporters in Clinical Pharmacology. Clinical pharmacology and therapeutics 112 (3) (2022)
Eugene C Chen, Pär Matsson, Mina Azimi, Xujia Zhou, Niklas Handin, Sook Wah Yee, Per Artursson, Kathleen M Giacomini
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3. Pharmaceutical research 39 (7) (2022)
Kathleen M Giacomini, Sook Wah Yee, Megan L Koleske, Ling Zou, Pär Matsson, Eugene C Chen, Deanna L Kroetz, Miles A Miller, Elnaz Gozalpour, Xiaoyan Chu
New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium. Clinical pharmacology and therapeutics 112 (3) (2022)
Megan L Koleske, Gregory McInnes, Julia E H Brown, Neil Thomas, Keino Hutchinson, Marcus Y Chin, Antoine Koehl, Michelle R Arkin, Avner Schlessinger, Renata C Gallagher, Yun S Song, Russ B Altman, Kathleen M Giacomini
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency. Proceedings of the National Academy of Sciences of the United States of America 119 (46) (2022)
Jennifer L Wilson, Kit Wun Kathy Cheung, Lawrence Lin, Elizabeth A E Green, Analia I Porrás, Ling Zou, David Mukanga, Paul A Akpa, Delese Mimi Darko, Rae Yuan, Sheng Ding, Wiltshire C N Johnson, Howard A Lee, Emer Cooke, Carl C Peck, Steven E Kern, Dan Hartman, Yoshikazu Hayashi, Peter W Marks, Russ B Altman, Murray M Lumpkin, Kathleen M Giacomini, Terrence F Blaschke
Scientific considerations for global drug development. Science translational medicine 12 (554) (2021)
Sook Wah Yee, Kathleen M Giacomini
Emerging Roles of the Human Solute Carrier 22 Family . Drug metabolism and disposition: the biological fate of chemicals (2021)
Ling Zou, Joshua Pottel, Natalia Khuri, Huy X Ngo, Zhanglin Ni, Eleftheria Tsakalozou, Mark S Warren, Yong Huang, Brian K Shoichet, Kathleen M Giacomini
Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP. Molecular pharmaceutics 17 (3) (2020)
Piet H van der Graaf, Kathleen M Giacomini
Clinical Pharmacology & Therapeutics 2030. Clinical pharmacology and therapeutics 107 (1) (2020)
Ling Zou, Peter Spanogiannopoulos, Lindsey M Pieper, Huan-Chieh Chien, Wenlong Cai, Natalia Khuri, Joshua Pottel, Bianca Vora, Zhanglin Ni, Eleftheria Tsakalozou, Wenjun Zhang, Brian K Shoichet, Kathleen M Giacomini, Peter J Turnbaugh
Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proceedings of the National Academy of Sciences of the United States of America 117 (27) (2020)
Joshua Pottel, Duncan Armstrong, Ling Zou, Alexander Fekete, Xi Ping Huang, Hayarpi Torosyan, Dallas Bednarczyk, Steven Whitebread, Barun Bhhatarai, Guiqing Liang, Hong Jin, Seyyed Nassir Ghaemi, Samuel T Slocum, Katalin V Lukacs, John J Irwin, Ellen L Berg, Kathleen M Giacomini, Bryan L Roth, Brian K Shoichet, Laszlo Urban
The activities of drug inactive ingredients on biological targets. Science (New York, N.Y.) 369 (6502) (2020)
Sven Lang, Tyler A Hilsabeck, Kenneth A Wilson, Amit Sharma, Neelanjan Bose, Deanna J Brackman, Jennifer N Beck, Ling Chen, Mark A Watson, David W Killilea, Sunita Ho, Arnold Kahn, Kathleen M Giacomini, Marshall L Stoller, Thomas Chi, Pankaj Kapahi
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. PLoS genetics 15 (8) (2019)
Osatohanmwen J Enogieru, Peter M U Ung, Sook Wah Yee, Avner Schlessinger, Kathleen M Giacomini
Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits. Human mutation 40 (7) (2019)
Ling Zou, Zhanglin Ni, Eleftheria Tsakalozou, Kathleen M Giacomini
Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters. Clinical pharmacology and therapeutics 105 (2) (2019)
Sook Wah Yee, Adrian Stecula, Huan-Chieh Chien, Ling Zou, Elena Valeryevna Feofanova, Marjolein van Borselen, Kit Wun Kathy Cheung, Noha A Yousri, Karsten Suhre, Jason M Kinchen, Eric Boerwinkle, Roshanak Irannejad, Bing Yu, Kathleen M Giacomini
Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. PLoS genetics 15 (9) (2019)
Xiaoyan Chu, Mingxiang Liao, Hong Shen, Kenta Yoshida, Arik A Zur, Vikram Arya, Aleksandra Galetin, Kathleen M Giacomini, Imad Hanna, Hiroyuki Kusuhara, Yurong Lai, David Rodrigues, Yuichi Sugiyama, Maciej J Zamek-Gliszczynski, Lei Zhang, null null
Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium. Clinical pharmacology and therapeutics 104 (5) (2019)
Kathleen M Giacomini, Aleksandra Galetin, Shiew Mei Huang
The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development. Clinical pharmacology and therapeutics 104 (5) (2019)
Xiaomin Liang, Sook Wah Yee, Huan-Chieh Chien, Eugene C Chen, Qi Luo, Ling Zou, Meiling Piao, Arias Mifune, Ligong Chen, Meredith E Calvert, Sarah King, Frode Norheim, Janna Abad, Ronald M Krauss, Kathleen M Giacomini
Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. PLoS biology 16 (4) (2018)
Huan-Chieh Chien, Claire Colas, Karissa Finke, Seth Springer, Laura Stoner, Arik A Zur, Brooklynn Venteicher, Jerome Campbell, Colton Hall, Andrew Flint, Evan Augustyn, Christopher Hernandez, Nathan Heeren, Logan Hansen, Abby Anthony, Justine Bauer, Dimitrios Fotiadis, Avner Schlessinger, Kathleen M Giacomini, Allen A Thomas
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). Journal of medicinal chemistry 61 (16) (2018)
Eugene C Chen, Natalia Khuri, Xiaomin Liang, Adrian Stecula, Huan-Chieh Chien, Sook Wah Yee, Yong Huang, Andrej Sali, Kathleen M Giacomini
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of medicinal chemistry 60 (7) (2017)
Natalia Khuri, Arik A Zur, Matthias B Wittwer, Lawrence Lin, Sook Wah Yee, Andrej Sali, Kathleen M Giacomini
Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1. Journal of chemical information and modeling 57 (6) (2017)
Adrian Stecula, Avner Schlessinger, Kathleen M Giacomini, Andrej Sali
Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer. Biochemistry 56 (27) (2017)