Antioxidant activity of Jeju lava seawater through translocation of Nrf2 in human fibroblast.
Hee Sun HeoYeong Eun KimJong Hun LeePublished in: Food science and biotechnology (2024)
Reactive oxygen species (ROS) are associated with various pathological conditions, including atherosclerosis and cancer. Photoaging, mainly caused by UVB-induced ROS, accelerates skin aging and collagen degradation. Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates antioxidant enzymes and has demonstrated protective effects against chronic diseases. Jeju lava seawater (JLS), which is rich in minerals, is attracting attention for its health benefits. The current study investigates the antioxidant properties of JLS in human dermal fibroblasts (HDFs). experiments were conducted by culturing HDFs in JLS with different water hardness levels and irradiating UVB. The results show that JLS does not affect HDF viability, especially at high water hardness. JLS treatment enhances collagen production and upregulates Nrf2 and antioxidant enzymes such as NQO1 and HO-1. This mechanism involves the translocation of Nrf2 to the cell nucleus. JLS shows promise as an antioxidant, potentially mitigating the effects of oxidative stress and promoting collagen synthesis.
Keyphrases
- oxidative stress
- diabetic rats
- reactive oxygen species
- dna damage
- wound healing
- nuclear factor
- endothelial cells
- ischemia reperfusion injury
- induced apoptosis
- high glucose
- toll like receptor
- healthcare
- induced pluripotent stem cells
- cell death
- public health
- cardiovascular disease
- pluripotent stem cells
- machine learning
- mental health
- molecularly imprinted
- stem cells
- papillary thyroid
- cell therapy
- inflammatory response
- young adults
- risk assessment
- type diabetes
- high resolution
- signaling pathway
- climate change
- squamous cell
- cell proliferation
- artificial intelligence
- extracellular matrix
- solid phase extraction
- childhood cancer
- health promotion