Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer.
Xiao LiuYilan JinTingting LiuShengju YangMengxue ZhouWeiqi WangHaijun YuPublished in: ACS biomaterials science & engineering (2020)
Chemodynamic therapy (CDT) has aroused extensive attention for cancer treatment in the last five years, as it could suppress tumor progression through in situ detrimental oxidative stress of the tumor cells via the Fenton reaction. Under a tumor acidic microenvironment, the Fenton reaction can be initiated for disproportioning endogenous hydrogen peroxide into highly toxic hydroxyl radical. Taking advantage of the highly tumor-specific therapy modality, various Fenton nanocatalysts have been developed for CDT. In particular, iron-containing Fenton nanocatalysts with minimal cytotoxicity exhibit great promise for clinical translation. In this review, we summarize the recent progress of CDT based on iron-containing nanomaterials, including iron oxide nanoparticles, glassy iron nanoclusters, ferrocene nanoparticles, metal polyphenol networks, metal-organic frameworks, etc. We also discuss the challenges and perspectives for promoting CDT by rational design of iron-containing nanomaterials, highlighting their potential for precise cancer therapy.
Keyphrases
- hydrogen peroxide
- cancer therapy
- iron deficiency
- nitric oxide
- wastewater treatment
- oxidative stress
- metal organic framework
- stem cells
- photodynamic therapy
- iron oxide nanoparticles
- poor prognosis
- drug delivery
- dna damage
- big data
- ischemia reperfusion injury
- risk assessment
- climate change
- mesenchymal stem cells
- fluorescent probe
- signaling pathway
- long non coding rna
- fluorescence imaging