Net clinical benefit of dual antiplatelet therapy in elderly patients with acute coronary syndrome: A systematic review and meta-analysis.

Tomohiro Fujisaki Toshiki KunoMasao IwagamiYoshihisa MiyamotoHisato Takagi Pierre DeharoThomas CuissetAlexandros BriasoulisSidakpal PanaichAzeem LatibShun Kohsaka

Published in: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2023)

Uniform de-escalation and short-term DAPT strategies may be advantageous for elderly patients, but need to be tailored based on individual bleeding and ischemic risks. Further RCTs of contemporary DAPT strategies specifically designed for elderly patients are warranted to confirm the findings of the present study.

Keyphrases

antiplatelet therapy
acute coronary syndrome
percutaneous coronary intervention
atrial fibrillation
open label
randomized controlled trial
smoking cessation
oxidative stress
ischemia reperfusion injury
climate change
community dwelling
cerebral ischemia