Development and Immunological Function of Lymph Node Stromal Cells.
Natalia Barbara PikorHung-Wei ChengLucas OnderBurkhard LudewigPublished in: Journal of immunology (Baltimore, Md. : 1950) (2021)
Stromal cells have for a long time been viewed as structural cells that support distinct compartments within lymphoid tissues and little more. Instead, an active cross-talk between endothelial and fibroblastic stromal cells drives the maturation of lymphoid niches, a relationship that is recapitulated during lymph node organogenesis, steady-state conditions, and following inflammation. In this review, we go over recent advances in genetic models and high-resolution transcriptomic analyses that have propelled the finer resolution of the stromal cell infrastructure of lymph nodes, revealing that the distinct subsets are strategically positioned to deliver a catered mixture of niche factors to interacting immune cell populations. Moreover, we discuss how changes in the activation state of poised stromal cell-underpinned niches rather than on-demand differentiation of new stromal cell subsets govern the efficient interaction of Ag, APC, and cognate B and T lymphocytes during adaptive immune responses.
Keyphrases
- lymph node
- single cell
- cell therapy
- high resolution
- bone marrow
- immune response
- neoadjuvant chemotherapy
- induced apoptosis
- rna seq
- squamous cell carcinoma
- endothelial cells
- peripheral blood
- dendritic cells
- radiation therapy
- mass spectrometry
- rectal cancer
- signaling pathway
- copy number
- cell cycle arrest
- cell proliferation
- locally advanced