The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras-MAPK Signaling in Epithelioid Hemangioendothelioma.

Shuang MaRyan KanaiAjaybabu V PobbatiShuo LiKepeng CheCaleb N SeaveyAndrea HallettAshley BurtscherJanine S A Warren Brian P Rubin

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Collectively, our results demonstrated that CTGF and the Ras-MAPK signaling cascade are essential for TC-mediated tumorigenesis. These studies provided the preclinical rationale for SARC033 (NCI 10015-NCT03148275), a nonrandomized, open-label, phase II study of trametinib in patients with unresectable or metastatic EHE.

Keyphrases

phase ii study
growth factor
open label
locally advanced
signaling pathway
squamous cell carcinoma
clinical trial
oxidative stress
wild type
pi k akt
phase iii
phase ii
small cell lung cancer
rectal cancer
placebo controlled
stem cells
randomized controlled trial
case control