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Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes.

Parna SahaDivya Tej SowpatiMamilla SoujanyaIshanee SrivastavaRakesh Kumar Mishra
Published in: Epigenetics & chromatin (2020)
Distinct pericentromeric genome organization and chromatin landscapes maintained by the interplay of heterochromatic factors (HP1a, H3K9me3, dMES-4 and dADD1) are sufficient to support heterochromatic gene expression despite the loss of global Het TAD structure. These findings open new avenues for future investigations into the mechanisms of heterochromatic gene expression.
Keyphrases
  • gene expression
  • genome wide
  • drosophila melanogaster
  • dna methylation
  • poor prognosis
  • dna damage
  • minimally invasive
  • single cell
  • binding protein
  • oxidative stress
  • bioinformatics analysis
  • genome wide analysis