Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer.
Qiuxia WangJian-Guo FengLiling TangPublished in: International journal of molecular sciences (2022)
The advancement in high-throughput sequencing analysis and the evaluation of chromatin state maps have revealed that eukaryotic cells produce many non-coding transcripts/RNAs. Further, a strong association was observed between some non-coding RNAs and cancer development. The mitogen-activated protein kinases (MAPK) belong to the serine-threonine kinase family and are the primary signaling pathways involved in cell proliferation from the cell surface to the nucleus. They play an important role in various human diseases. A few non-coding RNAs associated with the MAPK signaling pathway play a significant role in the development of several malignancies, including liver cancer. In this review, we summarize the molecular mechanisms and interactions of microRNA, lncRNA, and other non-coding RNAs in the development of liver cancer that are associated with the MAPK signaling pathway. Further, we briefly discuss the therapeutic strategies for liver cancer related to ncRNA and the MAPK signaling pathway.
Keyphrases
- signaling pathway
- pi k akt
- induced apoptosis
- cell cycle arrest
- epithelial mesenchymal transition
- cell proliferation
- cell surface
- protein kinase
- gene expression
- high throughput sequencing
- transcription factor
- genome wide
- papillary thyroid
- endoplasmic reticulum stress
- oxidative stress
- long non coding rna
- squamous cell
- young adults
- induced pluripotent stem cells
- long noncoding rna
- pluripotent stem cells
- cell death
- nucleic acid