Human periodontal ligament fibroblasts synthesize C-reactive protein and Th-related cytokines in response to interleukin (IL)-6 trans-signalling.

A Hernández-CalderaR VernalR ParedesP Veloso-MattaJ AstorgaMarcela Hernandez

Published in: International endodontic journal (2017)

IL-6 trans-signalling induced Th1 and Th17-related cytokines and represents an extra-hepatic mechanism for PCR synthesis in human periodontal ligament fibroblasts, contributing to explain the bone-destructive phenotype of apical lesions and eventually its systemic complications.

Keyphrases

endothelial cells
high glucose
induced pluripotent stem cells
pluripotent stem cells
extracellular matrix
diabetic rats
risk factors
oxidative stress
body composition
bone loss
real time pcr