Evaluation of chemotherapy toxicities in patients receiving treatment for gastrointestinal cancers and therapeutic monitoring of 5-fluorouracil as a clinical support tool.

Lucas Silva de BacoLaura Cé da SilvaLuis Carlos Moreira AntunesMarina Venzon AntunesRafael LindenMauber Eduardo Schultz MoreiraRicardo Bolsson RadinsSarayane Araújo Brandão MaranhãoSylvio Elvis da Silva BarbosaLucimara VolpatoLauren Razzera StefanonNatália Brucker

Published in: Fundamental & clinical pharmacology (2024)

These findings suggest that the evaluation of DPYD genotyping and DPD phenotyping in the Brazilian population still requires further study. Moreover, the analysis of the plasma AUC of 5-FU could contribute to clinical routine, being a very useful tool, especially for identifying patients outside the therapeutic range and thus guiding more individualized doses, or even in the intervention of possible toxicities related to overexposure.

Keyphrases

end stage renal disease
randomized controlled trial
newly diagnosed
ejection fraction
high throughput
chronic kidney disease
clinical practice
genome wide
gene expression
dna methylation
patient reported outcomes
combination therapy