Integrative in silico and in vitro transcriptomics analysis revealed new lncRNAs related to intrinsic apoptotic genes in colorectal cancer.
Fatemeh AkbariMaryam PeymaniAli SalehzadehKamran GhaediPublished in: Cancer cell international (2020)
This study developed a new data mining method to screen differentially expressed lncRNAs which are involved in regulation of intrinsic apoptosis pathway in CRC quickly using published gene expression profiling microarrays. Moreover, we could validate a number of these regulators in the cellular and laboratory disease models.
Keyphrases
- genome wide identification
- transcription factor
- genome wide
- genome wide analysis
- cell death
- single cell
- network analysis
- oxidative stress
- high throughput
- electronic health record
- cell cycle arrest
- endoplasmic reticulum stress
- dna methylation
- molecular docking
- big data
- randomized controlled trial
- systematic review
- anti inflammatory
- gene expression
- cell proliferation
- data analysis
- machine learning
- drug induced