Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.
Bachti AlisjahbanaRaspati Cundarani KoesoemadinataPanji Fortuna HadisoemartoBony Wiem LestariSri HartatiLidya ChaidirChuan-Chin HuangMegan MurrayPhilip Campbell HillSusan Margaret McAllisterPublished in: PloS one (2021)
Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB.
Keyphrases
- mycobacterium tuberculosis
- pulmonary tuberculosis
- network analysis
- randomized controlled trial
- healthcare
- quality improvement
- magnetic resonance imaging
- high resolution
- hiv aids
- mental health
- pulmonary hypertension
- physical activity
- high throughput
- hepatitis c virus
- depressive symptoms
- hiv infected
- magnetic resonance
- electron microscopy