Increased adipose tissue expression of IL-18R and its ligand IL-18 associates with inflammation and insulin resistance in obesity.

Rasheed AhmadReeby ThomasShihab KochumonSardar Sindhu

Published in: Immunity, inflammation and disease (2017)

The adipose tissue IL-18R/IL-18 expression is enhanced in obesity which associates with proinflammatory gene signature and insulin resistance in these individuals.

Keyphrases

adipose tissue
insulin resistance
poor prognosis
metabolic syndrome
type diabetes
high fat diet
oxidative stress
weight gain
high fat diet induced
binding protein
skeletal muscle
copy number
dna methylation
genome wide