Chronic ethanol exposure induces mitochondrial dysfunction and alters gene expression and metabolism in human cardiac spheroids.

Hyun HwangRui LiuRonald EldridgeXin HuParvin ForghaniDean P JonesChunhui Xu

Published in: Alcoholism, clinical and experimental research (2023)

Chronic ethanol treatment of hiPSC-CMs resulted in overall decreased mitochondrial function, increased glycolysis, disrupted fatty acid oxidation, and impaired cardiac structural development.

Keyphrases

gene expression
fatty acid
left ventricular
endothelial cells
dna methylation
hydrogen peroxide
drug induced
combination therapy
resting state
nitric oxide
atrial fibrillation