E2730, an uncompetitive GABA transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy.
Idrish AliJuliana C SilvaPablo Miguel Casillas-EspinosaEmma BraineGlenn R YamakawaMatthew R HudsonRhys D BradyBrendan MajorPeravina ThergarajanMohammad B HaskaliDavid K WrightBianca JuppLucy E VivashSandy R ShultzRichelle MychasiukPatrick KwanNigel Charles JonesKazuyuki FukushimaPallavi SachdevJocelyn Y ChengTerence J O'BrienPublished in: Epilepsia (2023)
This study shows that continuous subcutaneous infusion of E2730 over 7 days results in a marked, dose-dependent suppression of spontaneous recurrent seizures, with minimal adverse neurological effects, in a rat model of chronic MTLE. E2730 shows strong promise as an effective new ASM to be translated into clinical trials.