Hedgehog signaling is required for the maintenance of mesenchymal nephron progenitors.

Eunah ChungPatrick DeaconYueh-Chiang HuHee-Woong LimJoo-Seop Park

Published in: bioRxiv : the preprint server for biology (2023)

Our study demonstrates a previously unappreciated role of Hedgehog signaling in preventing premature depletion of mNPs by repressing Notch signaling and likely by activating the expression of pioneer factors.

Keyphrases

poor prognosis
stem cells
bone marrow
signaling pathway
binding protein